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AT-Cellyx
Streamlined cell mixing and cooling for advanced cell therapy manufacturing
The AT-Cellyx is an integrated equipment solution designed to optimize the final processing of cell therapies. It uniquely combines controlled mixing and cooling in a single, compact device, ensuring optimal product homogeneity and thermal stability. This innovation significantly reduces manual handling and seamlessly integrates into existing fill-finish setups, making it a simple, ready-to-use system for consistent, reproducible results from the first to the last drop.
Features & specifications
- Combines mixing & cooling in one device
- Ensures optimal product homogeneity
- Maintains thermal control (down to 2°C/35.6°F)
- Handles bulk sizes from 0.25L to 5L
- Cell concentrations of 10^6 to 50x10^7 cell/mL
- Compatible with AT-Closed Vial® technology filling lines
- Optional in-line cell counter for real-time monitoring
- Minimized product loss (less than 2mL once drained)
- Minimized shear stress to cells
- Compact, modular design for easy integration
- USP/EP compliant product contact parts
- Resistant to chemical cleaning agents (IPA)
- 110V/240V compatible
Integrated Mixing and Cooling for Cell Therapy Batches
The AT-Cellyx streamlines the final processing of cell therapy products through a controlled, integrated sequence.
- Bulk Loading and Connection: Cell bags are easily installed in the AT-Cellyx, leveraging compatibility with AT-Closed Vial® technology filling lines and the AT-Port system for seamless integration and sterility maintenance.
- Controlled Mixing Initiation: Once connected, the mixing process automatically starts to ensure optimal formulated product homogeneity by gentle, reproducible agitation.
- Integrated Thermal Control: Simultaneously with mixing, the integrated cooling system activates, maintaining the bulk product temperature precisely at 4°C +/- 2°C, with capability down to 2°C (39.2°F, with capacity down to 35.6°F).
- Optional In-Line Cell Counting: An optional, standalone in-line cell counter provides real-time monitoring of cell concentration before the filling step.
- Consistencyand Quality Assurance: The combined mixing and cooling ensures consistent vial to vial cell distribution during filling and minimizes product that is not well mixed (less than 2 doses), ensuring batch consistency and reducing manual handling errors.
- Product Discharge and Minimization of Loss: After processing, the system is designed to minimize product loss to less than 2ml once drained with a peristaltic pump, maximizing the yield from valuable cell therapy batches.
- Cleaning: The system is designed for easy manual cleaning after disposable product contact part removal.