The Crystal^® Technology, based on the Ready-to-Fill Closed Vial, enables safer and easier operations as it eliminates exposure to contamination and particles, and facilitates complete operations: from filling to the use by healthcare professionals.

The main advantages of the Crystal^® Technology are:

• Higher sterility assurance level and reduced particle contamination:

  • Vials and stoppers molded and directly closed in a ISO 5 clean room, followed by gamma irradiation for sterilization, ensure clean and sterile Ready-to-Fill Closed Vial;

  • Vial inside never exposed during the complete process as they remain closed, so each vial behave as an isolator;

  • Sterility assurance of the piercing area during storage maintained by the cap;

  • Meets latest authorities’ requirement for Good Manufacturing Practices.

• Elimination of the most complex steps of glass vial filling to simplify operations:

  • No vial/stopper washing, no siliconization, no sterilization, no depyrogenization, no cooling tunnel where open vials are exposed.

  • No stoppering, easy high-speed capping

  • No need for water for injection on the filling line

  • Reduced QA/QC at validation and on regular basis

•  Safer supply chain:

  • No spillage outside container during filling;

  • In line coding possible and ready for RFID identification and tracking;

  • Closed sterile container resistant to damages;

• Closed Vial preferred by end-users:

  • Easy handling;

  • Facilitated piercing through large surface and no risk of needle bending;

  • Better collection of all injectable product;

  • Unbreakable vial.

• Reduction of investment and operating expenses:

  • Reduced clean room space for the equipment (up to a factor three);

  • Residual volume in the vial reduced by stopper design can lead to lower overfill required;

  • Reduction of vial loss by breakage;

  • Less operators and less QA/QC work.